Review of juxtaglomerular cell tumor with focus on pathobiological aspect

نویسندگان

  • Naoto Kuroda
  • Hiroko Gotoda
  • Chisato Ohe
  • Shuji Mikami
  • Keiji Inoue
  • Yoji Nagashima
  • Fredrik Petersson
  • Isabel Alvarado-Cabrero
  • Chin-Chen Pan
  • Ondrej Hes
  • Michal Michal
  • Zoran Gatalica
چکیده

Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases.

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عنوان ژورنال:

دوره 6  شماره 

صفحات  -

تاریخ انتشار 2011