Human housekeeping genes are compact.

نویسندگان

  • Eli Eisenberg
  • Erez Y Levanon
چکیده

Genome Biol. 2, 1018 13 Gray, M.W. et al. (1999) Mitochondrial evolution. Science 283, 1476–1481 14 Lang, B.F. et al. (1999) A comparative genomics approach to the evolution of eukaryotes and their mitochondria. J. Eukaryot. Microbiol. 46, 320–326 15 Henze, K. and Martin, W. (2001) How do mitochondrial genes get into the nucleus? Trends Genet. 17, 383–387 16 Chinnery, P.F. (2003) Searching for nuclear-mitochondrial genes. Trends Genet. 19, 60–62 17 Emanuelsson, O. et al. (2000) Predicting subcellular localization of proteins based on their N-terminal amino acid sequence. J. Mol. Biol. 300, 1005–1016 18 Nakai, K. and Horton, P. (1999) PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization. Trends Biochem. Sci. 24, 34–36 19 Bannai, H. et al. (2002) Extensive feature detection of N-terminal protein sorting signals. Bioinformatics 18, 298–305 20 Karlberg, O. et al. (2000) The dual origin of the yeast mitochondrial proteome. Yeast 17, 170–187 21 Marcotte, E.M. et al. (2000) Localizing proteins in the cell from their phylogenetic profiles. Proc. Natl. Acad. Sci. U. S. A. 97, 12115–12120 22 Germot, A. et al. (1997) Evidence for loss of mitochondria in Microsporidia from a mitochondrial-type HSP70 in Nosema locustae. Mol. Biochem. Parasitol. 87, 159–168 23 Katinka, M.D. et al. (2001) Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi. Nature 414, 450–453 24 Martin, W. et al. (2002) Evolutionary analysis of Arabidopsis, cyanobacterial, and chloroplast genomes reveals plastid phylogeny and thousands of cyanobacterial genes in the nucleus. Proc. Natl. Acad. Sci. U. S. A. 99, 12246–12251 25 Millar, A.H. et al. (2001) Analysis of the Arabidopsis mitochondrial proteome. Plant Physiol. 127, 1711–1727 26 Taylor, S.W. et al. (2003) Global organellar proteomics. Trends Biotechnol. 21, 82–88 27 Leister, D. (2003) Chloroplast research in the genomic age. Trends Genet. 19, 47–56

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On the nature of human housekeeping genes.

Using a collection of expressed sequence tag (EST) data, we re-evaluated the correlation of tissue specificity with genomic structure, phyletic age, evolutionary rate and promoter architecture of human genes. We found that housekeeping genes are less compact and older than tissue-specific genes, and they evolve more slowly in terms of both coding and core promoter sequences. Housekeeping genes ...

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Do housekeeping genes, which are turned on most of the time in almost every tissue, evolve more slowly than genes that are turned on only at specific developmental times or tissues? Recent large-scale gene expression studies enable us to have a better definition of housekeeping genes and to address the above question in detail. In this study, we examined 1581 human-mouse orthologous gene pairs ...

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‘Genome design’ model and multicellular complexity: golden middle

Human tissue-specific genes were reported to be longer than housekeeping genes (both in coding and intronic parts). The competing neutralist and adaptationist models were proposed to explain this observation. Here I show that in human genome the longest are genes with the intermediate expression pattern. From the standpoint of information theory, the regulation of such genes should be most comp...

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عنوان ژورنال:
  • Trends in genetics : TIG

دوره 19 7  شماره 

صفحات  -

تاریخ انتشار 2003