Dhea supplementation and cognition in postmenopausal women.
نویسندگان
چکیده
Previous work has suggested that DHEA supplementation may have adverse cognitive effects in elderly women. This article analyzed 24-h measurements of DHEA, DHEAS, and cortisol to determine if cognitive decrease with treatment is mediated by DHEA's impact on endogenous cortisol. It was found that DHEA administration increased cortisol at several hours during the day. In the treatment group, cortisol was positively associated with cognition at study completion. An increase in negative associations between DHEA(S) levels and cognition was found at completion. Increased cortisol does not explain the cognitive deficits associated with DHEA, suggesting a direct negative effect of exogenous DHEA on cognition.
منابع مشابه
Long-term low-dose dehydroepiandrosterone oral supplementation in early and late postmenopausal women modulates endocrine parameters and synthesis of neuroactive steroids.
OBJECTIVE To evaluate the effects of a low-dose DHEA supplementation on hormonal parameters in early and late postmenopausal women. DESIGN Prospective case study. SETTING Postmenopausal women in a clinical research environment. PATIENT(S) Twenty postmenopausal women were divided in two groups according to age (50-55 and 60-65 years). INTERVENTION(S) All patients underwent hormonal evalu...
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ورودعنوان ژورنال:
- The International journal of neuroscience
دوره 116 2 شماره
صفحات -
تاریخ انتشار 2006