A Quantitative Study of the Cross Reaction of Types Iii and Viii Pneumococci in Horse and Rabbit Antisera

1. A preparation of the specific polysaccharide of Type VIII pneumococcus is described in which the use of heat, strong acid, and alkali were avoided. 2. Quantitative estimations are given of the homologous and cross reacting precipitin and agglutinin in Types III and VIII antisera produced in the rabbit and in the horse. Quantitative data are also given on the mechanism of the Type VIII precipitin reaction and the cross reaction between the Type III polysaccharide and Type VIII antipneumococcus horse serum. 3. The significance of the data is discussed.