Persistent infection of a human lymphoblastoid cell line with equine herpesvirus 1.

Coevolution of virulent virus and resistant cells as a mechanism of persistence of herpes simplex virus type 1 in a human T lymphoblastoid cell line.

Infection of the lymphoblastoid CEM cell line with herpes simplex virus (HSV) type 1 results in a persistent infection with production of infectious virus. Evidence suggests that the persistent infection was not maintained by interferon or non-interferon-soluble antiviral inhibitors. Treatment of persistently infected cells with anti-HSV serum (termed CEMACR cells) or elevated temperature (39 d...

Equine herpesvirus type 1-mediated oncolysis of human glioblastoma multiforme cells.

The cytolytic animal virus equine herpesvirus type 1 (EHV-1) was evaluated for its oncolytic potential against five human glioblastoma cell lines. EHV-1 productively infected four of these cell lines, and the degree of infection was positively correlated with glioma cell death. No human major histocompatibility complex class 1 (MHC-I) was detected in the resistant glioma line, while infection o...

Inhibition of the mitogenic response of normal peripheral lymphocytes by extracts or supernatant fluids of a Herpesvirus saimiri lymphoid tumor cell line.

A Herpesvirus saimiri-infected marmoset lymphoid cell line (MLC-1) was examined for the presence of soluble factors which might affect lymphocyte functions and, therefore, relate to the pathogenesis of lymphoma in vivo. MLC-1 cells, cell extracts, and culture fluids were shown to reduce the spontaneous deoxyribonucleic acid (DNA) synthesis of normal peripheral blood lymphocytes and to completel...

Growth and persistent infection of African horse-sickness virus in a mosquito cell line

Association of pityriasis rosea with Human Herpesvirus-6

Background: Pityriasis rosea (PR) is a common papulosquamousskin disorder that is suspected to have an infectious etiology.We aimed to study the role of human herpesvirus-6 (HHV-6) inthe pathogenesis of PR.Method: We used immunohistochemical (IHC) assays to detectHHV-6 in patients with PR. Fifty-one patients with PR and 35 ageand sex matched healthy control samples were enrolled in thestudy. Th...