HTLV-1 -associated Myelopathy
نویسنده
چکیده
Chronic progressive spastic paraparesis occurring in tropical areas and southwest Japan is frequently associated with high antibody titers to HTLV-1 in serum and cerebrospinal fluid.12 We recently reported that T-lymphocyte alveolitis occurred in patients with HTLV-1-associated myelopathy (HAM).3 The presence of such pulmonary lesions were also described by Vernant and associates in patients with HTLV-1-associated tropical spastic paraparesis (HTLV1ITSP).4 In the present study, bronchoalveolar lavage (BAL) fluid had an increased proportion of lymphocytes in patients with HAM (ten women and three men, 50 ± 17 percent), compared to HTLV-1negative normal control subjects (ten nonsmoking male volunteers, 14 ± 3 percent). Increased BAL lymphocytes consisted mainly of CD3 + cells (78 ± 17 percent) and CD4 + /CD8 + ratios (1.5 ± 0.8) were similar to those ofnormal control subjects (1.3 ±0.7). Serum levels ofsoluble interleukin-2 receptors (IL-2R), a marker of T-cell activation,5 were significantly elevated in patients with HAM compared to normal control subjects (685 ± 210 vs 286 ± 49 U/mI, p<O.Ol). Soluble IL-2R levels were detectable in BAL fluid from HAM patients and BAL levels were approximately 13 times higher than those in serum (166± 103 vs 18± 13 U/mg albumin, p = 0.001). BAL IL-2R levels in HAM patients correlated well with the number of lymphocytes and T-cells in BAL fluid (r=0.68, p<0.05 and r=0.64, p<O.O5, respectively). These results suggest that T-lymphocytes infiltrating the lungs of HAM patients are activated locally to produce IL-2R. Our data show that bronchoalveolar T-Iymphocytosis occurs in patients with HAM ,suggesting that immunologic mechanisms play an important role in the development of pulmonary lesions in HAM.
منابع مشابه
The Impact of Immune Response on HTLV-I in HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)
Human T lymphotropic virus type I (HTLV-I) is a retrovirus which is associated with adult T cells leukaemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a minority of HTLV-I-infected individuals. It is not clear why a minority of HTLV-I-infected individuals develop HAM/TSP and majority remains lifelong carriers. It seems that the interaction between the v...
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HTLV-1-associated infective dermatitis and probable HTLV-1- associated myelopathy in an adolescent female*
Human T cell lymphotropic virus type 1 (HTLV-1)-associated infective dermatitis (ID) is a chronic, severe and recurrent eczema occurring during childhood in patients vertically infected with HTLV-1. HTLV-1-associated myelopathy/tropical spastic paraparesia (HAM/ TSP) is slow and progressive. We report the case of an adolescent female from a non-endemic area for HTLV-1 who presents ID and, most ...
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To investigate candidate genes that influence the risk of HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), we analyzed 6 single nucleotide polymorphisms (SNP) in the interleukin-10 (IL-10) promoter region. METHODS: 280 cases of HAM/TSP patients and 255 HTLV-I seropositive asymptomatic carriers (HCs) from Kagoshima, Japan were studied. All subjects gave written informed conse...
متن کاملPolymorphism in the interleukin-10 promoter affects both provirus load and the risk of human t lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis
To investigate candidate genes that influence the risk of HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), we analyzed 6 single nucleotide polymorphisms (SNP) in the interleukin-10 (IL-10) promoter region. METHODS: 280 cases of HAM/TSP patients and 255 HTLV-I seropositive asymptomatic carriers (HCs) from Kagoshima, Japan were studied. All subjects gave written informed conse...
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