Extensive squamous metaplasia (morules) of the otherwise normal endometrium: a case report with immunohistochemical studies.

An immunohistochemical study was performed with the use of Dako’s EnVision method, as previously described [6, 7]. The results are shown in Table 1. The morules were positive for pancytokeratins (AE1/3 and CAM5.2), cytokeratin (CK) 34BE12, CK5/6, CK8, CK19, Ki-67 (labeling=1%) and p63, but were negative for CK7, CK14, CK20, p53, vimentin, CA125, S100 protein, desmin, CEA, α-smooth muscle antigen (ASMA), EMA, CD34, estrogen receptor (ER), and progesterone receptor (PgR). In contrast, the endometrial glands were positive for pancytokeratin (AE1/3 and CAM5.2), CK7, CK8, CK18, CK19, p53, Ki-67 (labeling=7%), p63, CA125, EMA, ER and PgR, but were negative for CK34BE12, CK5/6, CK14, CK20, vimentin, S100 protein, desmin, CEA, ASMA, and CD34.