Inhibition of Low Density Lipoprotein-oxidation, ACAT-1, and ACAT-2 by Lignans from the Bark of Machilus thunbergii
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چکیده
Sabina Shrestha, Ji-Hae Park, Dae-Young Lee, Jin-Gyeong Cho, Do-Gyeong Lee, Moon-Hee Cho, Tae-Sook Jeong, Hee-Cheol Kang, and Nam-In Baek * Graduate School of Biotechnology, Institute of Life Sciences & Resources, Kyung Hee University, Yongin 446-701, Republic of Korea Korea Research Institute of Bioscience & Biotechnology, Daejeon 305-806, Republic of Korea R&D Center, Green Flower Cosmetics Co., Suwon 443-813, Republic of Korea
منابع مشابه
Lignans from the bark of Machilus thunbergii and their DNA topoisomerases I and II inhibition and cytotoxicity.
Activity-guided fractionation based on topoisomerase I inhibitory activity lead to the isolation of ten lignans (1-10) from the methylene chloride extract of the bark of Machilus thunbergii SIEB. et ZUCC. (Lauraceae). These were identified as machilin A (1), erythro-austrobailignan-6 (2), meso-monomethyl dihydroguaiaretic acid (3), meso-dihydroguaiaretic acid (4), galbacin (5), machilin F (6), ...
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The bioassay-guided fractionation of the methylene chloride soluble portion of a methanol extract of Machilus thunbergii bark led to the isolation of four known lignans, machilin A (1), meso-monomethyl dihydroguaiaretic acid (2), nectandrin A (3) and nectandrin B (4), which exhibited potent inhibitory activity on melanin biosynthesis in cultured B-16 mouse melanoma cells (IC(50): 39.9, 15.1, 19...
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