2-Adrenergic responsiveness in human skeletal muscle feed arteries: the role of TRPV ion channels in heat-induced sympatholysis
نویسندگان
چکیده
Jayson R. Gifford, Stephen J. Ives, Song-Young Park, Robert H. I. Andtbacka, John R. Hyngstrom, Michelle T. Mueller, Gerald S. Treiman, Christopher Ward, Joel D. Trinity, and Russell S. Richardson Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, Utah; Department of Exercise and Sport Science, University of Utah, Salt Lake City, Utah; Department of Health and Exercise Sciences, Skidmore College, Saratoga Springs, New York; Department of Surgery, Huntsman Cancer Hospital, University of Utah, Salt Lake City, Utah; Division of Surgery, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, Utah; and Department of Internal Medicine, University of Utah, Salt Lake City, Utah
منابع مشابه
α1- and α2-adrenergic responsiveness in human skeletal muscle feed arteries: the role of TRPV ion channels in heat-induced sympatholysis.
The purpose of this study was to determine if heat inhibits α2-adrenergic vasocontraction, similarly to α1-adrenergic contraction, in isolated human skeletal muscle feed arteries (SMFA) and elucidate the role of the temperature-sensitive vanilloid-type transient receptor potential (TRPV) ion channels in this response. Isolated SMFA from 37 subjects were studied using wire myography. α1 [Phenyle...
متن کاملHeat and α1-adrenergic responsiveness in human skeletal muscle feed arteries: the role of nitric oxide.
Increased local temperature exerts a sympatholytic effect on human skeletal muscle feed arteries. We hypothesized that this attenuated α(1)-adrenergic receptor responsiveness may be due to a temperature-induced increase in nitric oxide (NO) bioavailability, thereby reducing the impact of the α(1)-adrenergic receptor agonist phenylephrine (PE). Thirteen human skeletal muscle feed arteries were h...
متن کاملHIGHLIGHTED TOPIC Skeletal and Cardiac Muscle Blood Flow Role of nitric oxide in exercise sympatholysis
Buckwalter, John B., Jessica C. Taylor, Jason J. Hamann, and Philip S. Clifford. Role of nitric oxide in exercise sympatholysis. J Appl Physiol 97: 417–423, 2004. First published March 12, 2004; 10.1152/japplphysiol.01181.2003.—The production of nitric oxide is the putative mechanism for the attenuation of sympathetic vasoconstriction (sympatholysis) in working muscles during exercise. We hypot...
متن کاملExercise attenuates a-adrenergic-receptor responsiveness in skeletal muscle vasculature
Buckwalter, John B., Jay S. Naik, Zoran Valic, and Philip S. Clifford. Exercise attenuates a-adrenergic-receptor responsiveness in skeletal muscle vasculature. J Appl Physiol 90: 172–178, 2001.—Attenuation of sympathetic vasoconstriction (sympatholysis) in working muscles during dynamic exercise is controversial. A potential mechanism is a reduction in a-adrenergic-receptor responsiveness. The ...
متن کاملExercise attenuates alpha-adrenergic-receptor responsiveness in skeletal muscle vasculature.
Attenuation of sympathetic vasoconstriction (sympatholysis) in working muscles during dynamic exercise is controversial. A potential mechanism is a reduction in alpha-adrenergic-receptor responsiveness. The purpose of this study was to examine alpha(1)- and alpha(2)-adrenergic-receptor-mediated vasoconstriction in resting and exercising skeletal muscle using intra-arterial infusions of selectiv...
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