On the Poisons of Amanita Phalloides
نویسنده
چکیده
It has recently been shown by one of us (W. W. Ford’) that the poisons of the fungus Amanita phalloides, the variety responsible for the great majority of deaths from mushroom intoxication, belong to the group of bacterial toxins. They were thus classified in virtue of their causing characteristic lesions in animals after a definite latent period, and because an immunity may be established toward them in susceptible animals after the administration of non-lethal doses. The serum obtained by Ford from his immunized animals was antihiemolytic and antitoxic in character; it prevented the solution of blood corpuscles in vitro and neutralized the poisonous action of the fungus on animals. Fords also proved that the heemolytic principle first described by Kobert under the name phallin, as the only poison present in the fungus, is in fact accompanied by a highly toxic, thermostabile substance devoid of haemolytic properties, whose presence can be demonstrated by biological experiments. For this thermostabile substance an antitoxin3 can be produced devoid of any antihzmolytic action and Ford has proposed for it the provisional name Amanita Toxin. In view of the importance that attaches to the physical and chemical properties of toxins in elucidating questions of immunity it was determined to make a chemical study of the poisons of Amanita phalloides.’
منابع مشابه
On the Poisons of Amanita Phalloides
It has recently been shown by one of us (W. W. Ford’) that the poisons of the fungus Amanita phalloides, the variety responsible for the great majority of deaths from mushroom intoxication, belong to the group of bacterial toxins. They were thus classified in virtue of their causing characteristic lesions in animals after a definite latent period, and because an immunity may be established towa...
متن کاملAmanita phalloides poisoning and treatment with silibinin in the Australian Capital Territory and New South Wales.
OBJECTIVES To report the frequency and clinical outcomes of Amanita phalloides poisoning in the Australian Capital Territory and New South Wales, and the treatments used (including silibinin). DESIGN, SETTING AND PATIENTS Retrospective case series of patients admitted to public hospitals in Canberra and Sydney for suspected A. phalloides poisoning between 1999 and 2012 (identified from hospit...
متن کاملThe Effects of N-acetylcysteine in Patients with Amanita phalloides Intoxication
Conclusions: Amanita phalloides intoxication can be successfully treated with N-acetylcysteine in addition to the standard regimen. Significantly, the simplicity of administration, good tolerance, and an affordable cost make N-acetylcysteine a viable option for the treatment of Amanita phalloides intoxication. The low mortality rate presented in the study group may be ascribed to N-acetylcystei...
متن کاملDistribution and abundance of the introduced ectomycorrhizal fungus Amanita phalloides in North America.
Despite a growing awareness of the global reach of ectomycorrhizal (EM) fungal introductions, little is known about the fate of introduced EM fungi in novel ranges. Using herbarium specimens, species distribution models, and field collections of sporocarps, root tips and extramatrical mycelia, we assessed the distribution and abundance of the European species Amanita phalloides in North America...
متن کامل