Evaluating pharmaceutical R&D under technical and economic uncertainty

Optimal production strategy of bimetallic deposits under technical and economic uncertainties using stochastic chance-constrained programming

In order to catch up with reality, all the macro-decisions related to long-term mining production planning must be made simultaneously and under uncertain conditions of determinant parameters. By taking advantage of the chance-constrained programming, this paper presents a stochastic model to create an optimal strategy for producing bimetallic deposit open-pit mines under certain and uncertain ...

Real options valuation under uncertainty

In this paper we develop a novel valuation model and methodology to value a pharmaceutical R&D project based on real options approach. The real options approach enables the possibility of optimally abandon the project before completion whenever the investment cost turns out to be larger than the expected net cash flow stream. On the other hand, the proposed model accounts for two different sour...

Foreign Investment as Main Factor for Successful Funds and Its Effect on Trade Balance Strategic Technology Adoption under Technological Uncertainty

Application of Sequential Gaussian Conditional Simulation to Underground Mine Design Under Grade Uncertainty

In mining projects, all uncertainties associated with a project must be considered to determine the feasibility study. Grade uncertainty is one of the major components of technical uncertainty that affects the variability of the project. Geostatistical simulation, as a reliable approach, is the most widely used method to quantify risk analysis to overcome the drawbacks of the estimation methods...

Robust production scheduling in open-pit mining under uncertainty: a box counterpart approach

Open-Pit Production Scheduling (OPPS) problem focuses on determining a block sequencing and scheduling to maximize Net Present Value (NPV) of the venture under constraints. The scheduling model is critically sensitive to the economic value volatility of block, block weight, and operational capacity. In order to deal with the OPPS uncertainties, various approaches can be recommended. Robust opti...