Vortioxetine (brintellix): a new serotonergic antidepressant.
نویسندگان
چکیده
Vortioxetine (Brintellix): a new serotonergic antidepressant.
منابع مشابه
Vortioxetine (brintellix) for the treatment of depression.
The safety profile of vortioxetine is similar to that of other selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors. As with other antidepressants in this class, vortioxetine includes a black box warning of increased risk of suicidal thoughts and behavior in children, adolescents, and young adults. It may also cause clinical worsening or activation of mania o...
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This article summarized the available knowledge on clinically relevant drug interactions of vortioxetine, a new antidepressant with a “multimodal” serotonergic mechanism of action, recently approved for the treatment of major depressive disorder. Although information is still limited and mainly based on studies performed in healthy volunteers, vortioxetine appears to have a favorable drug inter...
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Vortioxetine is an antidepressant that targets multiple pharmacologic modes of action at sites--or nodes--where serotonergic neurons connect to various brain circuits. These multimodal pharmacologic actions of vortioxetine lead to enhanced release of various neurotransmitters, including serotonin, at various nodes within neuronal networks.
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Monoamine-based treatments for depression have evolved greatly over the past several years, but shortcomings such as suboptimal efficacy, treatment lag, and residual cognitive dysfunction are still significant. Preclinical and clinical studies using compounds directly targeting glutamatergic neurotransmission present new opportunities for antidepressant treatment, with ketamine having a surpris...
متن کاملDrug interactions with vortioxetine, a new multimodal antidepressant Interazioni farmacologiche della vortioxetina, un nuovo antidepressivo ad azione multimodale
Multiple drug therapy is common in clinical psychiatry practice and carries the risk of drug interactions. A drug interaction occurs when the effectiveness or toxicity of a drug is altered by the concomitant administration of another pharmacological agent. In a few cases drug interactions may prove beneficial, leading to increased efficacy or reduced risk of unwanted effects, and therefore cert...
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ورودعنوان ژورنال:
- P & T : a peer-reviewed journal for formulary management
دوره 40 1 شماره
صفحات -
تاریخ انتشار 2015