Is Histologic Subtype Significant in the Management of NSCLC?
نویسندگان
چکیده
Histologic subtype has emerged as a potential prognostic and/or predictive factor in advanced non-small cell lung cancer (NSCLC). Several studies support the importance of differentiating between squamous and non-squamous NSCLC in terms of efficacy of chemotherapeutics (e.g. pemetrexed) or treatment-related toxicities (e.g. bevacizumab). In addition, molecular markers and gene profiles have been correlated with histologic subtype. This review examines the emerging clinical significance of histologic type in the management of NSCLC, discusses caveats in accurate histologic diagnosis, and reviews biomarkers with potential predictive value for NSCLC chemotherapeutics.
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