Facile Three-component Synthesis of imidazo[4,5-b]indoles
نویسنده
چکیده
A survey of the pertinent literature reveals that aryl imidazoles have been found to possess a wide spectrum of biological activity such as antibacterial [1], antirheumatoid arthritis [2], antitubercular [3], antiviral [4], anti-inflammatory [5] and anticancer activities [6-8]. Specifically, it has been revealed from the literature that imidazoles fused with indole nucleus possess various biological activities [9-11] including anticancer activity especially against breast cancer.
منابع مشابه
Iodine mediated intramolecular C2-amidative cyclization of indoles: a facile access to indole fused tetracycles.
A novel and metal-free I2-mediated intramolecular C2 amidation of indoles under mild reaction conditions is developed. This methodology affords various indole fused tetracyclic compounds, such as benzo[4,5]imidazo[1,2-a]indoles by intramolecular C2 amidation of N-aryl substituted indoles. This C2 sulfonamidative cyclization also offers convenient access to indolo[2,3-b]indoles and dihydroindolo...
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