Dynamics of Pathomorphological Changes in Rat Ischemic Spinal Cord after Treatment with Recombinant Erythropoietin: Experimental Study

MATERIALS AND METHODS: The study was conducted on 40 mature rats. The animals were divided into two series of experiments, 20 animals each. The first series of animals was the group compared to the spinal cord ischemia model. In the second series 1000 international units (0.0084 mg) of REP in 3, 24, and 48 hours were administered intraperitoneally to the animals. After the animals had been sacrificed, the spinal cord was removed for further histologic and morphometric study. The obtained results were processed using analysis of variance. The statistical significance of differences between the compared parameters of the groups was assessed with the Mann-Whitney U test.