A new chemo-enzymatic route to chiral 2-hydroxy-4-phenylbutyrates by combining lactonase-mediated resolution with hydrogenation over Pd/C.

نویسندگان

  • Bing Chen
  • Hai-Feng Yin
  • Zhen-Sheng Wang
  • Jia-Ying Liu
  • Jian-He Xu
چکیده

A new chemo-enzymatic route to both isomers of 2-hydroxy-4-phenylbutyric acid is reported. The key step is the lactonase-catalyzed hydrolysis of cis- and trans-2-hydroxy-4-phenyl-4-butyrolactones followed by hydrogenation over Pd/C to afford optically pure 2-hydroxy-4-phenylbutyric acid.

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عنوان ژورنال:
  • Chemical communications

دوره 46 16  شماره 

صفحات  -

تاریخ انتشار 2010