Annual Review of Chronopharmacology
نویسندگان
چکیده
The f r a c t i o n a l d i s t r i b u t i o n o f l y m p h o c y t e subsets was d e t e r m i n e d i n t h r e e m a l e s u b j e c t s . I t s c o n t r i b u t i o n t o t h e c i r c a d i a n v a r i a t i o n i n t h e exp r ess i on o f ß2~adrenoceptor s i t e s on pe r iphera l m o n o n u c l e a r l e u c o c y t e s ( M N L ) was c a l c u l a t e d t o be 92 .7 -107 .3 % o f t h e 2 4 h m e a n . Th is s t r o n g l y f a v o r s t h e i d e a t h a t t h e a c t u a l l y obse r v ed c i r c a d i a n r a n g e o f 7 4 . 5 124.9 % of the 2 4 h m e a n c o n s t i t u t e s a c i r c a d i a n r e c e p t o r d o w n a n d u p r e g u l a t i o n .
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