Candida albicans-derived beta-1,2-linked mannooligosaccharides induce desensitization of macrophages.
نویسندگان
چکیده
Candida albicans beta-1,2-oligomannosides stimulate macrophage tumor necrosis factor alpha (TNF-alpha) but not NO release. This stimulation desensitized macrophages by altering beta-1, 2-oligomannoside-dependent TNF-alpha production and lipopolysaccharide-dependent TNF-alpha and NO secretion. Desensitization was not related to tyrosine phosphorylation signal transduction but was transferred by culture supernatants in which arachidonic acid derivatives were evidenced.
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ورودعنوان ژورنال:
- Infection and immunity
دوره 68 2 شماره
صفحات -
تاریخ انتشار 2000