Are Two Exclusions Enough to Exclude in Paternity Testing? Analysis of 17 Str, D1s80 and Hla-a, B, Drb, and Dqb1 in Two Cases with Only Two Exclusions
نویسندگان
چکیده
It is widely accepted that two or more STR exclusions are enough to exclude in a paternity testing dispute. Routinely we analyze 12 Short Tandem repeat loci (STR) in our paternity testing program. When only one or two exclusions are found, we increase the number of STR analyzed to 17 plus D1S80 in order to find additional exclusions (Power of exclusion 99.9999%). Occasionally, the highly discriminating HLA system by molecular typing is also performed if required.
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In parentage testing when one parent is excluded, the distribution of the number of loci showing exclusion due to mutations of the transmitting alleles is derived, and it is contrasted with the expected distribution when the exclusion is caused by nonpaternity. This theory is applied to allele frequency data on short tandem repeat loci scored by PCR analysis, and VNTR data scored by Southern bl...
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