Cannabinoid Regulation of Serotonin 2A (5-HT2A) Receptor Signaling
نویسندگان
چکیده
......................................................................................................................................... iii Acknowledgements ......................................................................................................................... v List of Figures and Tables.............................................................................................................. xi List of Abbreviations ................................................................................................................... xiv Chapter 1: Introduction ................................................................................................................... 1 Chapter 2: Review of Literature ..................................................................................................... 4 2.1 Cannabinoids ......................................................................................................................... 4 2.1.1 Endocannabinoids ........................................................................................................... 4 2.1.2 Phytocannabinoids .......................................................................................................... 7 2.1.3 Synthetic Cannabinoids .................................................................................................. 7 2.1.4 Selective Cannabinoid Receptor Agonists and Antagonists........................................... 8 2.2 Cannabinoid Receptors ......................................................................................................... 9 2.2.1 CB1 Receptor Gene and Structural Characteristics ........................................................ 9 2.2.2 CB2 Receptor Gene and Structural Characteristics ...................................................... 10 2.2.3 CB1 and CB2 Receptor Localization ............................................................................. 12 2.2.4 Cellular Signaling of CB1 and CB2 Receptors.............................................................. 12 2.3 Additional Cannabinoid Targets ......................................................................................... 15 2.4 Cannabinoids, Cannabinoid Receptors, and Neuropsychiatric Disorders ........................... 15 2.5 Serotonergic System in the Brain ........................................................................................ 17
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