Prognostic Value of Focal Positive Surgical Margins After Radical Prostatectomy. - PubMed - NCBI
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چکیده
The data were analyzed retrospectively for 1733 patients with clinically localized prostate cancer who had undergone RP at our institution from December 2003 to March 2014 without neoadjuvant or adjuvant therapy. Positive surgical margins were characterized as FPMs (≤ 3 mm long) or non-FPMs (> 3 mm long). Multivariate analysis of the clinicopathologic factors, including FPMs, was performed with respect to biochemical recurrence (BCR)-free survival.
منابع مشابه
[Positive surgical margins after radical prostatectomy]. - PubMed - NCBI
Abstract Positive surgical margins (PSMs) in radical prostatectomy specimens are usually considered a negative prognostic parameter. However, their definition and the management of patients with PSMs remain unclear. The aim of the present review is to define pathological features of PSMs,to report their incidence and risk factors and to update PSMs prognostic meaning and possible treatment moda...
متن کاملDo margins matter? The prognostic significance of positive surgical margins in radical prostatectomy specimens. - PubMed - NCBI
The prognostic significance of positive surgical margins (PSM) in radical prostatectomy (RP) specimens remains unclear. While most studies have concluded that a PSM is an independent adverse prognostic factor, others report that surgical margin status has no effect on prognosis. One reason for these discordant conclusions is the variable number of patients with a PSM who receive adjuvant therap...
متن کاملThe actual value of the surgical margin status as a predictor of disease progression in men with early prostate cancer.
OBJECTIVES The surgical margin status after radical prostatectomy for prostate cancer has long been considered a powerful prognostic factor, as well as an important risk factor for local recurrent disease after radical prostatectomy. In this study, a critical analysis of the predictive value of the surgical margin status was performed. METHODS A well-described cohort of 281 participants of a ...
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Gleason grading of prostatic specimens remains as one of the most powerful factors predicting prognosis in patients with prostate cancer. This grading system was created by Donald Gleason about 49 years ago and it takes into account the 2 most prevalent grades in the tumor sample, but it does not consider the presence of a third high grade pattern when it represents less than 5% of the whole ra...
متن کاملDeterminants and effects of positive surgical margins after prostatectomy on prostate cancer mortality: a population-based study
BACKGROUND The objective of this population-based study was to assess patient, physician and tumour determinants associated with positive surgical margins after prostatectomy, and to assess the effects of positive surgical margins on prostate cancer-specific survival. METHODS We included 1'254 prostate cancer patients recorded at the Geneva Cancer Registry who had radical prostatectomy during...
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