The porphyrinogenic effects of kryptopyrrole in the rat and the occurrence of urinary kryptopyrrole in human hereditary hepatic porphyria.
نویسندگان
چکیده
1. Kryptopyrrole (2,4-dimethyl-3-ethyl pyrrole) was shown to elevate the urinary porphyrin excretion and the hepatic content of porphyrins in the rat. The simultaneous administration of sigma-aminolaevulinic acid increased these effects. 2. Kryptopyrrole was present in the urine of patients with hereditary hepatic porphyria, in attack and in remission, but not in those with latent porphyria.
منابع مشابه
Pharmacological and toxic effects of kryptopyrrole in mice.
Preliminary findings indicate that patients with acute intermittent porphyria excreted increased amounts of urinary kryptopyrrole during acute attacks associated with neuropsychiatric symptoms (Irvine and Wetterberg, 1971). These symptoms of acute porphyria are of special interest since they are sometimes of schizophrenic type (Waldenstrom, 1937; Peters, 1962) or constitute a porphyria mental s...
متن کاملA Rapid Screening Test for Pyroluria; Useful in Distinguishing a Schizophrenic Subpopulation
An assay procedure is presented which has proven extremely useful in delineating a subpopulation of schizophrenic patients. The procedure is a highly sensitive rapid screening test for urinary pyrroles such as kryptopyrrole and urobilinogen. An extensive investigation of this test and the original assay procedure for kryptopyrrole described by Irvine indicates that free kryptopyrrole arises pri...
متن کاملUrinary Pyrrole in Health and Disease
Urinary pyrrole, also known as the mauve factor (malvaria), pyrroluria and kryptopyrrole, was first described in the 1950s. It was found in the urine of patients undergoing experimental LSD treatments. When reacted with Ehrlich’s reagent (p-dimethylamino benzaldehyde), several of the urines developed a purple or “mauve” color. This colored compound was first thought to be an indole. In 1961, a ...
متن کاملThe decrease in uroporphyrinogen decarboxylase activity induced by ethanol predisposes rats to the development of porphyria and accelerates xenobiotic-triggered porphyria, regardless of hepatic damage.
We evaluated the porphyrinogenic ability of ethanol (20% in drinking water) per se, its effect on the development of sporadic porphyria cutanea tarda induced by hexachlorobenzene in female Wistar rats (170-190 g, N = 8/group), and the relationship with hepatic damage. Twenty-five percent of the animals receiving ethanol increased up to 14-, 25-, and 4.5-fold the urinary excretion of delta-amino...
متن کاملPseudoporphyria in association with Hepatitis C virus infection: A case report
Pseudoporphyria is an uncommon bullous disease with similar clinical and histopathological findings to porphyria cutanea tarda, in the absence of detectable porphyrin elevation. We present a 34-year-old man with clinical and histological findings compatible with porphyria cutanea tarda, whose his urinary uroporphyrin was negative and we concluded that he was a case of pseudoporphyria. Concomita...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Clinical science and molecular medicine
دوره 50 5 شماره
صفحات -
تاریخ انتشار 1976