Response to Comment on Nishio et al. on Diabetes Reversal in NOD Mice
نویسندگان
چکیده
Contrary to previous findings, we found no significant differentiation of splenocytes into pancreatic islet cells in nonobese diabetic (NOD) mice treated with an immune adjuvant and allogenic spleen cells. We show that our single-nucleotide polymorphism assay has the requisite sensitivity to support our contention. The experiments of Faustman et al. lack adequate controls, and we maintain that no evidence of islet regeneration has been presented.
منابع مشابه
Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice.
Chong et al., Nishio et al., and Suri et al. (Reports, 24 March 2006, pp. 1774, 1775, and 1778) confirmed that treating nonobese diabetic (NOD) mice with an immune adjuvant and semisyngenic spleen cells can reverse the disease but found that spleen cells did not contribute to the observed recovery of pancreatic islets. We show that islet regeneration predominately originates from endogenous cel...
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