High throughput solubility determination with application to selection of compounds for fragment screening.
نویسندگان
چکیده
The development and application of a high throughput aqueous solubility assay is reported. Measurements for up to 637 compounds can be made in a fully automated experiment. Results from this assay were used to quantify risk of unacceptable solubility as a function of lipophilicity for neutral fragment-like compounds. Assessment of risk of unacceptable solubility was combined with experimental solubility measurement to select compounds for inclusion in a fragment-screening library.
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Fragment library design_Layout 1
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry
دوره 16 13 شماره
صفحات -
تاریخ انتشار 2008