Heat production by brown adipocytes of FOK rats genetically resistant to a hot environment.
نویسندگان
چکیده
The FOK rat was established as an inbred strain with genotypic adaptation to a hot environment. To investigate the mechanism of the heat resistance of FOK rats, heat production by isolated brown adipocytes in FOK and WKAH rats was measured at 37.0 and 39.9 degrees C. Basal heat production by brown adipocytes of FOK rats was not significantly different from that of WKAH rats. Isoproterenol increased the heat production in a dose-dependent manner in both strains, while 10(-9) M isoproterenol caused a significant increase in WKAH rats and a negligible change in FOK rats. These results indicate that the reason why FOK rats are resistant to the severe heat is partly due to the low heat production by brown adipocytes.
منابع مشابه
Parallel measurements of heat production and thermogenin content in brown fat cells during cold acclimation of rats.
The maximum thermogenic capacity of brown fat cells from control and cold acclimated rats was measured using a continuous-flow microcalorimetric system. The content of the 32.000 D, brown fat specific protein, thermogenin, was measured in the cells used for heat production measurements by competitive ELISA. The ratio between the maximal thermogenic capacity and the amount of thermogenin for con...
متن کاملThermoregulatory responses of the inbred heat-tolerant FOK rat to cold.
The responses of inbred heat-tolerant FOK rats to cold were compared with those of Wistar King A/H (WKAH) and Std:Wistar (WSTR) strains. The fall of colonic temperature during cold exposure was unexpectedly smaller in FOK than in other groups, but the onset of shivering was delayed in FOK. Norepinephrine (NE)-induced in vivo oxygen consumption and the mitochondrial uncoupling protein 1 level of...
متن کاملThermoeffector thresholds and preferred ambient temperatures of the FOK rat.
The FOK is an inbred rat strain with a genotypic adaptation to hot environments. The present study compared the thermoeffector thresholds and preferred ambient temperatures (Tpref) of the FOK rat with those of other rat strains. Male FOK, WKAH, and Donryu rats were used. First, they were loosely restrained and placed individually in a metabolic chamber with an ambient temperature of 26.0°C. The...
متن کاملRegulation mode of evaporative cooling underlying a strategy of the heat-tolerant FOK rat for enduring ambient heat.
Compared with other rat strains, the inbred FOK rat is extremely heat tolerant. This increased heat tolerance is due largely to the animal's enhanced saliva spreading abilities. The aims of the present study were to 1) quantify the heat tolerance capacity of FOK rats and 2) determine the regulatory mode of the enhanced salivary cooling in these animals. Various strains of rats were acutely expo...
متن کاملEffects of Heat and Lead on the Reproductive System of Male Wistar Rat
Introduction: Wistar rats are an outbred strain of albino rats belonging to the species Rattus norvegicus. Histopathological studies on the testis was carried out to determine the effects of heat and lead on male fertility by evaluating some andrological parameters of the wistar rat such as morphology of spermatozoa, sperm count and motility. The main objective of this research was to compare t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of veterinary medical science
دوره 59 12 شماره
صفحات -
تاریخ انتشار 1997