Richard E . Waters , Svein Rotevatn , Ping Li , Brian H . Annex and Zhen Yan angiogenesis in mouse skeletal muscle Voluntary running induces fiber type - specific
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[PDF] [Full Text] [Abstract] , November 1, 2007; 103 (5): 1815-1823. J Appl Physiol M. J. Lyon, L. M. Steer and L. T. Malmgren human posterior cricoarytenoid muscle Stereological estimates indicate that aging does not alter the capillary length density in the [PDF] [Full Text] [Abstract] , July 1, 2008; 295 (1): C288-C292. Am J Physiol Cell Physiol T. Akimoto, P. Li and Z. Yan exercise by in vivo imaging Functional interaction of regulatory factors with the Pgc-1{alpha} promoter in response to [PDF] [Full Text] [Abstract] , December 15, 2008; 586 (24): 6021-6035. J. Physiol. K. A. Zwetsloot, L. M. Westerkamp, B. F. Holmes and T. P. Gavin necessary for the angiogenic response to exercise AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not [PDF] [Full Text] [Abstract] , May 1, 2009; 106 (5): 1660-1667. J Appl Physiol L. E. Wong, T. Garland Jr., S. L. Rowan and R. T. Hepple mice Anatomic capillarization is elevated in the medial gastrocnemius muscle of mighty mini [PDF] [Full Text] [Abstract] , June 1, 2009; 94 (6): 749-760. Exp Physiol M. H. Malek and I. M. Olfert exercise capacity in mice Global deletion of thrombospondin-1 increases cardiac and skeletal muscle capillarity and
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Voluntary running induces fiber type-specific angiogenesis in mouse skeletal muscle.
Adult skeletal muscle undergoes adaptation in response to endurance exercise, including fast-to-slow fiber type transformation and enhanced angiogenesis. The purpose of this study was to determine the temporal and spatial changes in fiber type composition and capillary density in a mouse model of endurance training. Long-term voluntary running (4 wk) in C57BL/6 mice resulted in an approximately...
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Skeletal muscle undergoes active remodeling in response to endurance exercise training, and the underlying mechanisms of this remodeling remain to be defined fully. We have recently obtained evidence that voluntary running induces cell cycle gene expression and cell proliferation in mouse plantaris muscles that undergo fast-to-slow fiber-type switching and angiogenesis after long-term exercise....
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The fiber specificity of skeletal muscle abnormalities in chronic heart failure (CHF) has not been defined. We show here that transgenic mice (8 weeks old) with cardiac-specific overexpression of calsequestrin developed CHF (50.9% decrease in fractional shortening and 56.4% increase in lung weight, P<0.001), cachexia (37.8% decrease in body weight, P<0.001), and exercise intolerance (69.3% decr...
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Endurance exercise stimulates peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) expression in skeletal muscle, and forced expression of PGC-1alpha changes muscle metabolism and exercise capacity in mice. However, it is unclear if PGC-1alpha is indispensible for endurance exercise-induced metabolic and contractile adaptations in skeletal muscle. In this study, we s...
متن کاملPGC-1 plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle
Tuoyu Geng,* Ping Li,* Mitsuharu Okutsu, Xinhe Yin, Jyeyi Kwek, Mei Zhang, and Zhen Yan Department of Medicine, Duke University Medical Center, Durham, North Carolina; Cardiovascular and Metabolic Diseases Program, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore, Singapore; and Department of Medicine-Cardiovascular Medicine, Center for Skeletal Muscle Research at ...
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