MCPIP 1 mediates silica - induced cell migration in human pulmonary 1 fibroblasts
نویسندگان
چکیده
MCPIP1 mediates silica-induced cell migration in human pulmonary 1 fibroblasts 2 Running Title: MCPIP1 induced pulmonary fibroblast migration 3 Haijun Liu, Xiaoniu Dai, Yusi Cheng, Shencun Fang, Yingming Zhang, 4 Xingang Wang, Wei Zhang, Hong Liao, Honghong Yao, Jie Chao 5 6 Department of Physiology, School of Medicine, Southeast University, Nanjing, 7 Jiangsu, 210009, China 8 Neurobiology Laboratory, New Drug Screening Centre, China Pharmaceutical 9 University, Nanjing, Jiangsu, 210009, China 10 Nine Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, 11 Jiangsu, 210029, China 12 Department of Pharmacology, School of Medicine, Southeast University, 13 Nanjing, Jiangsu, 210009, China 14 Key Laboratory of Developmental Genes and Human Disease, Southeast 15 University, Nanjing, 210096, China 16 Department of Respiration, Zhongda Hospital, School of Medicine, Southeast 17 University, Nanjing, Jiangsu 210009 18
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MCPIP1 mediates silica-induced cell migration in human pulmonary fibroblasts.
Silicosis is a systemic disease caused by inhaling silicon dioxide (SiO2). Phagocytosis of SiO2 in the lungs initiates an inflammatory cascade that results in fibroblast proliferation and migration followed by fibrosis. According to previous data from our laboratory, monocyte chemotactic protein-1 (MCP-1) plays a critical role in fibroblast proliferation and migration in conventional two-dimens...
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