Update on Advances in Polypoidal Choroidal Vasculopathy - A Subtype of Subretinal Neovascularization

Polypoidal choroidal vasculopathy (PCV) is a subtype of subretinal neovascularization and a variant of agerelated macular degeneration. Recent advances in diagnosis and treatment of this disease entity have improved the management of PCV and its outcomes. The diagnosis of PCV is often made based on funduscopic findings, but more definitively on indocyanine green angiography (ICGA) patterns. OCT, OCT-A and en face OCT offer alternative ways to diagnose PCV if ICG angiography is not available. The treatment of PCV is controversial but options include photodynamic therapy (PDT), anti-vascular endothelial growth factor (anti-VEGF) therapy, and laser photocoagulation. Anti-VEGF therapy is an important therapeutic option for PCV, but alternative treatment may be needed with resistance to injections. While PDT results in greater closure of the PCV complex and polyp regression, anti-VEGF therapy has been shown to have signifiChapter 1