Antiproliferative Properties of Embelia Ribes
نویسندگان
چکیده
Embelia ribes is a threatened woody shrub belonging to the family Myrsinaceae, which is sparsely distributed in the moist deciduous forests of the Western Ghats in India. The previous reports showed the effect of Embelin in methylcholanthrene induced fibrosarcoma in albino rats besides enhancing their survival time. Embelin provided a good support for the chemopreventive effect against Nnitrosodiethylamine/ phenobarbital induced hepatocarcinogenesis in Wistar rats. The present studies on cancer cell lines revealed that the crude hexane extract of the fruits of Embelia ribes exhibited cytotoxicity against Human leukaemic cells (K562) and Dalton’s Lymphoma ascites cells (DLA). Bioactivity directed fractionation and isolation yielded Embelin as the active principle. Invitro studies on Embelin suggests the potential of the compound on these two cell lines. However the compound did not exhibit toxicity on normal lymphocytes isolated from human blood preferentially attacking the tumour cells. This is the first report of invitro cytotoxic activity of Embelia ribes.
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In vitro Evaluation of Antifungal Activity of the Seed Extract of Embelia Ribes
Antifungal activity of Embelia ribes was evaluated on eight different fungal species by employing various concentrations of seed extract (0.5-2.0 mg). All the concentrations of seed extract inhibited the fungal growth, whereas maximum activity was observed at 2.0 mg concentration of seed extract. Among different doses, the diameter of inhibition zones ranged from 9 to 18 mm in various fungal sp...
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Embelia ribes Burm F. is large scandent shrub, disturbed throughout India and belongs to the family Myrsinacae. It is commonly known as false black pepper or Vidanga. E. ribes grows in semievergreen and deciduous forests at an altitude of 1,500m found in central and lower Himalayas, Arunachal Pradesh, Assam, Bengal, Orissa, Andhra Pradesh and Madhya Pradesh throughout India. Embelia ribes has b...
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A simple, rapid and economical procedure for estimation of Embelin by UV Spectrophotometer in Embelia ribes was developed and is described. The method is based on the identification of Embelin by TLC and on the ultra violet absorbance maxima in chloroform at 285 nm. A value of 4.80% w/w of Embelia was found in test simple.
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