IMMUNOBIOLOGY Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia
نویسندگان
چکیده
1Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN; 2Department of Pathology, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA; 3Department of Therapeutic Radiology, University of Minnesota, Minneapolis, MN; 4Department of Molecular Immunology, Tokyo Medical and Dental University, Tokyo, Japan; 5Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, PA; 6Department of Dermatology, University of California Davis, Davis, CA; and 7Department of Pediatrics, School of Medicine, Medical College of Georgia, Augusta, GA
منابع مشابه
Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.
Tumor-induced immune defects can weaken host immune response and permit tumor cell growth. In a systemic model of murine acute myeloid leukemia (AML), tumor progression resulted in increased regulatory T cells (Treg) and elevation of program death-1 (PD-1) expression on CD8(+) cytotoxic T cells (CTLs) at the tumor site. PD-1 knockout mice were more resistant to AML despite the presence of simil...
متن کاملProgram death-1 (PD-1) signaling and regulatory T cells (Tregs) collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes (CTLs) in advanced acute myeloid leukemia (AML) Running title: PD-1 blockade and adoptive CTL therapy for AML
Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation and Department of Therapeutic Radiology, University of Minnesota, Minneapolis, MN; Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA; Department of Molecular Immunology, Tokyo Medical and Dental University, Tokyo, Japan; Abramson Family Cancer Research Inst...
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