Targeting the ErbB Family in Head and Neck Cancer
نویسندگان
چکیده
Head and neck cancer is the sixth most common cancer, representing about 5% of all cancers. Each year, more than half a million new cases are diagnosed worldwide.1–3 Over the past decade, the important role of different growth factors and their receptors and signal transduction pathways in the genesis and progression of tumours has been well recognised, and their mechanism of action and interaction is gradually being unravelled.4–10 The ErbB family comprises four members: human epidermal growth factor receptor (EFGR; HER 1), HER2 (c-erb-B2), HER3 (cerb-B3) and HER4 (c-erb-B4).
منابع مشابه
The Epidermal Growth Factor Receptor (egfr) Pathway in Cancer Part Ii — Target Cancer Indications
COPYRIGHT © 2007 NEW MEDICINE INC. UNAUTHORIZED PHOTOCOPYING, DISTRIBUTION OR ELECTRONIC STORAGE IS PROHIBITED BY LAW. THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY IN CANCER PART II — TARGET CANCER INDICATIONS AND TARGETING APPROACHES ERBB RECEPTORS ASSOCIATION BY CANCER INDICATION 1958 EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) 1959 Colorectal Cancer 1959 Head and Neck Cancer 1960 Lung Can...
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