Lipodermatosclerosis: successful treatment with danazol.

Sir, Lipodermatosclerosis (LDS), also reported as liposclerosis, hypodermatitis sclerodermaformis, sclerosing panniculitis, pseudoscleroderma, indurated cellulitis, stasis panniculitis and chronic cellulitis, is characterized by a scleroderma-like induration of the skin and a typical ‘inverted champagne bottle’ sign. Although considerable progress has been made in understanding the pathophysiology, no unifying therapeutic concept exists and the efficiency of the various treatment options has been reported very controversially. In the present case we describe successful treatment of LDS with the weak androgen danazol.