Observations on thymectomy and carcinogenesis.

Paradoxical Effect of Three-Day Thymectomy on Sarcogenesis in the Mouse with Different Dosages of Methylcholanthrene1

Past studies have shown that thymectomy in the mouse at 3 days of age but not at birth or after 7 days produces, in later life, a variety of localized autoimmune lesions. In the present work, 3-day thymectomy facilitated subsequent sarcogenesis by low dosages of 3-methylcholanthrene but inhibited oncogenesis by a high dosage. If the presence of autoimmunity implies an increased antitumor immuni...

Paradoxical effect of three-day thymectomy on sarcogenesis in the mouse with different dosages of methylcholanthrene.

Past studies have shown that thymectomy in the mouse at 3 days of age but not at birth or after 7 days produces, in later life, a variety of localized autoimmune lesions. In the present work, 3-day thymectomy facilitated subsequent sarcogenesis by low dosages of 3-methylcholanthrene but inhibited oncogenesis by a high dosage. If the presence of autoimmunity implies an increased antitumor immuni...

Observations on the Nature of Myasthenia Gravis. the Effect of Thymectomy on Neuro-muscular Transmission.

اثر درمانی تایمکتومی در بیماران مبتلا به میاستنی گراویس

Background: Myasthenia Gravis (MG) is a neuromuscular disorder with weakness of skeletal muscles. Thymectomy is now recognized as a treatment modality in MG. The aim of this study was to evaluate the clinical effect of thymectomy on MG. Methods: MG patients with history of thymectomy at a tertiary referral center during twelve year period were included. The medical records were reviewed and te...

MYASTHENIA GRAVIS AND THYMECTOMY: A 10-YEAR STUDY IN SHIRAZ

A retrospective comparative study was performed on 54 patients treated medically or surgically (thymectomy) for myasthenia gravis (MG) from 1979- 1989 in three Shiraz University Hospitals. Each surgical patient was compared with a medical patient on the basis of age, sex, severity and duration of disease. Complete remission was noted in 3 out of 27 thymectomized patients but in none of the...