Measurement of benzo(a)pyrene metabolism in human monocytes.
نویسندگان
چکیده
منابع مشابه
ارزیابی میزان مواجهه تنفسی با بنزو آلفا پیرن(Benzo (a) Pyrene) در آسفالتکاران شهر تهران
Background: Asphalt workers are exposed to dangerous agents in his workplace that might result in occupational diseases. Benzo (a) pyrene as a human carcinogen, is emission from hot asphalt and asphalt workers are exposed with it. The aim of this study was, evaluation of respiratory exposure to benzo (a) pyrene among asphalt workers. Method: In this study, 42 samples were collected from breath...
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An assay has been developed and measurements of aryl hydrocarbon [benzo(a)pyrene] hydroxylase have been made in peripheral blood monocytes from a human population. Treatment with benz(a)anthracene in cell culture increased aryl hydrocarbon hydroxylase activity from 6.5 to 37-fold in monocytes from each of 25 apparently healthy donors. A weak correlation (r = 0.38) was observed between the induc...
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The metabolism of benzo(a)pyrene has been investigated in cultured normal human bronchus, colon, duodenum, and esophagus obtained from the same patient. The highest total metabolism was found in bronchus and duodenum, while the highest mean binding level was observed in the bronchus followed, in order, by the esophagus, duodenum, and trans verse colon. A 30-fold interindividual variation in the...
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The metabolism of benzo(a)pyrene by human liver microsomes and human lymphocytes has been analyzed by high-pressure liquid chromatography. Human liver forms seven known metabolites and at least five additional unidentified metabolites that migrate as distinct peaks. Lymphocytes incubated with benzo(a)pyrene for 30 min do not form dihydrodiols. Lymphocytes incubated for 24 hr with benzo(a)pyrene...
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Human placenta is a readily available organ that responds to maternal environmental insult and has been previously used to investigate metabolism and bioactivation of procarcinogens, for example, benzo[a]pyrene. HPLC in combination with synchronous fluorescence spectroscopy was used to examine 28 placentas for the presence of benzo[a]pyrene diol epoxide-DNA adducts, and 10 of these were found t...
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ورودعنوان ژورنال:
- Cancer research
دوره 37 8 Pt 1 شماره
صفحات -
تاریخ انتشار 1977