Local immunotherapy with ONCOS-102 shapes harmful tumor associated CD68+ macrophages to become beneficial cells that correlate with increased overall survival
نویسندگان
چکیده
Local immunotherapy with ONCOS-102 shapes harmful tumor associated CD68+ macrophages to become beneficial cells that correlate with increased overall survival Sari Pesonen, Johan Lundin, Nina Linder, Riku Turkki, Ari Ristimäki, Timo Joensuu, Kalevi Kairemo, Kaarina Partanen, Tuomo Alanko, Elke Jäger, Julia Karbach, Claudia Wahle, Akseli Hemminki, Charlotta Backman, Mikael von Euler, Tiina Hakonen, Tuuli Ranki, Antti Vuolanto, Magnus Jäderberg, Dmitry Zamarin
منابع مشابه
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Late stage cancer is often associated with reduced immune recognition and a highly immunosuppressive tumor microenvironment. The presence of tumor infiltrating lymphocytes (TILs) and specific gene-signatures prior to treatment are linked to good prognosis, while the opposite is true for extensive immunosuppression. The use of adenoviruses as cancer vaccines is a form of active immunotherapy to ...
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BACKGROUND Both tumor-associated macrophages (TAMs) and the epithelial to mesenchymal transition (EMT) of cancer cells play key roles in promoting tumor progression. However, whether TAMs could induce EMT in the progression of oral squamous cell carcinoma (OSCC) remains undefined. RESULTS Here we detected the expression of macrophages markers CD68 and CD163, epithelial marker E-cadherin and m...
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2015