Asymmetric hydrogenation of α,α'-disubstituted cycloketones through dynamic kinetic resolution: an efficient construction of chiral diols with three contiguous stereocenters.
نویسندگان
چکیده
Chiral diols with three contiguous stereocenters were synthesized by a highly enantioselective ruthenium-catalyzed asymmetric hydrogenation of racemic α,α'-disubstituted cycloketones involving dynamic kinetic resolution. This new catalytic asymmetric method provides a concise route to the alkaloid (+)-γ-lycorane.
منابع مشابه
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متن کاملIridium-catalyzed asymmetric hydrogenation of racemic α-substituted lactones to chiral diols† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc04609f Click here for additional data file.
We report a protocol for the highly efficient iridium-catalyzed asymmetric hydrogenation of racemic a-substituted lactones via dynamic kinetic resolution. Using Ir-SpiroPAP (R)-1d as a catalyst, a wide range of chiral diols were prepared in a high yield (80–95%) with a high enantioselectivity (up to 95% ee) under mild reaction conditions. This protocol was used for enantioselective syntheses of...
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 52 2 شماره
صفحات -
تاریخ انتشار 2013