Palindrome Mediated Translocation in Human: Where Do We Go from Here?
نویسندگان
چکیده
Palindromes are two groups of identical sequences which join each other in inverted direction. The palindrome mediated genomic instability contributes to a diverse group of genomic rearrangements like translocations, deletions, and amplifications. Palindrome involve in translocation have AT richness (PATRRs) and the best suited examples of this is t(11;22) translocation. PATRR22 is a hotspot of palindrome mediated translocation. Several molecular methods involve in identification of various PATRRs which modulate translocation by mechanism of double strand break (DSB), especially in gametogenesis. However, the precise mechanism of DSB, cloning of critical translocating factor PATRR22, enzymatic pathways and timing involved in formation of PATRRs translocations in gametogenesis is still undiagnosed.
منابع مشابه
Two different forms of palindrome resolution in the human genome: deletion or translocation.
Regions containing palindromic sequence are known to be susceptible to genomic rearrangement in prokaryotes and eukaryotes. Palindromic AT-rich repeats (PATRR) are hypervariable in the human genome, manifesting size polymorphisms and a propensity to rearrange. Size variations are mainly the result of internal deletions, while two PATRRs on 11q23 and 22q11 (PATRR11 and 22) contribute to generati...
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