RECENT CSF AND POSTMORTEM BRAIN HYPOCRETIN MEASUREMENTS IN HUMAN NARCOLEPSY SUGGEST THAT HYPOCRETIN DEFICIENCY IS INVOLVED IN THE PATHOPHYSIOLOGY OF THE DISEASE.1,2 Extended studies
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چکیده
RECENT CSF AND POSTMORTEM BRAIN HYPOCRETIN MEASUREMENTS IN HUMAN NARCOLEPSY SUGGEST THAT HYPOCRETIN DEFICIENCY IS INVOLVED IN THE PATHOPHYSIOLOGY OF THE DISEASE.1,2 Extended studies in idiopathic and symptomatic narcolepsy, as well as in various neurological conditions, suggest that CSF hypocretin-1 measures could be used as a diagnostic tool for narcolepsy.3,4 Although the levels in selected healthy adult populations tested fall in a relatively narrow range (age: 22-62 years old, range: 230-376 pg/ml, mean+/-SD: 280+/-33 pg/ml),3 whether CSF hypocretin-1 levels fluctuate with age or by gender has not been fully studied. This information is essential for understanding the pathogenesis of hypocretin deficiency in narcoleptic subjects. In order to investigate the developmental change of hypocretin concentrations, we measured CSF hypocretin-1 levels across an age range from infants to elderly people.
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