Folic acid malabsorption in cardiac failure.
نویسندگان
چکیده
The association of malnutrition with chronic cardiac failure has been recognized for many years, and the occurrence of intestinal malabsorption was first recorded in 1938 when Bologna and Costadoni measured, by fat balance, the degree of steatorrhoea in 20 patients with congestive cardiac failure. Malabsorption of neutral fat has been repeatedly observed (Langen, 1953; Hakkila, Makela, and Halonen, 1960; Jones, 1961; Berkowitz, Croll, and Likoff, 1963) but impaired absorption of other nutrients is less well documented. In the present study the intestinal absorption of folic acid has been investigated in patients with various types of congestive cardiac failure and the results have been related to other evidence of malabsorption. These observations have been compared with similar tests in normal subjects, in patients with folate deficiency without malabsorption, and in patients with steatorrhoea.
منابع مشابه
Cardiac Failure and Folate Deficiency
SIR,-Your interesting leading article on cardiac failure and folate deficiency (24 January, p. 188) commented on the possible causes of this association, and factors like impaired dietary intake and gastrointestinal malabsorption were mentioned. A contributory cause could well be excessive folate loss in the urine. Urinary folate excretion has been poorly studied, but we recently reported an un...
متن کاملComparison of the Diagnostic Accuracy of Three Com- Mercially Available Enzyme Immunoassays for Anti-p53
malabsorption could be a risk factor in the development of these diseases. Because bacterial metabolism alters folic acid status and intestinal bacterial colonization is altered by nutritional factors and carbohydrate malabsorption syndromes, dietary measurements should not rely solely on folic acid supplementation but should also consider carbohydrate malabsorption syndromes, especially fructo...
متن کاملWernicke's Encephalopathy, Wet Beriberi, and Polyneuropathy in a Patient with Folate and Thiamine Deficiency Related to Gastric Phytobezoar
Background. Wernicke's encephalopathy (WE) is an acute neurological disorder resulting from thiamine deficiency. It is mainly related to alcohol abuse but it can be associated with other conditions such as gastrointestinal disorders. This vitamin deficiency can also present with cardiovascular symptoms, called "wet beriberi." Association with folate deficit worsens the clinical picture. Subject...
متن کاملUrinary excretion of formiminoglutamic acid in children with riboflavin deficiency.
An increased excretion of urinary formiminoglutamic acid (FIGLU) following an oral dose of histidine has been reported in various conditions other than folic acid deficiency,1 viz., vitamin B12 deficiency,2 hepatic cirrhosis,3,4 malabsorption syndrome,4 megaloblastic anemia associated with pregnancy and malnutrition,5 hemolytic anemia,6 iron-deficiency anemia,5 neoplastic disease,6 thyrotoxicos...
متن کاملFolic acid deficiency in congestive heart failure.
The purpose of this report is to indicate that deficiency of folic acid occurs with notable frequency in patients with past or immediate congestive heart failure. The study described was stimulated by the clinical examination of two anaemic patients with heart disease whose bone-marrows showed morphological features consistent with a lack of this haematinic. There were several additional reason...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Gut
دوره 9 6 شماره
صفحات -
تاریخ انتشار 1968