Anesthetic implications in stiff-person syndrome.

Stiff-person syndrome (SPS) is a rare neurologic disease manifested by persistent muscle contractions causing marked rigidity in the affected individual . There are many case descriptions and clinical reviews in the neurologic literature, outlining a progression of knowledge from the early clinical description of SPS to advanced molecular biologic and immunologic studies implicating the gamma-aminobutyric acid (GABA) receptor system . We report a case of prolonged hypotonicity after general anesthesia in a patient with SPS and discuss the possible anesthetic interactions.