Thioridazine (Melleril) retinopathy.
نویسندگان
چکیده
The drug thioridazine was first introduced in I959 and Weekley, PQtts, Reboton, and May (I960) reported the first cases of pigmentary retinopathy, in four patients who had been given approximately 2 g. daily for 30-50 days. The manufacturers (Sandoz) subsequently recommended that a daily dose of 8oo mg. should not be exceeded and since then only about half a dozen articles have appeared (all in American publications) relating to this condition. We have been unable to find any cases of thioridazine-induced retinopathy reported from Europe or England. The following is the first case to be reported from Australia and it is illustrated for the first time by a fluorescein fundus photograph.
منابع مشابه
Is thioridazine retinopathy progressive? Relationship of pigmentary changes to visual function.
Thioridazine toxicity has been described as a 'progressive chorioretinopathy', but this designation can be misleading. During the first year after thioridazine exposure retinal pigmentation evolves from a granular to a patchy or nummular appearance. However, visual function and the electroretinogram typically improve during this period. Some cases may show chorioretinal atrophy and functional l...
متن کاملPediatric thioridazine poisoning as a result of a pharmacy compounding error
The adverse effects or overdose of thioridazine including sudden death, fatal arrhythmia, or retinopathy, in addition to the neurological signs have been reported. A three-year-old boy with bronchitis was prescribed erythromycin by a local clinic, but he started to complain of severe drowsiness and became unconscious. It was decided that this was a result of a compounding error of thioridazine ...
متن کاملTargeting Lung Cancer Stem Cells with Antipsychological Drug Thioridazine
Lung cancer stem cells are a subpopulation of cells critical for lung cancer progression, metastasis, and drug resistance. Thioridazine, a classical neurological drug, has been reported with anticancer ability. However, whether thioridazine could inhibit lung cancer stem cells has never been studied. In our current work, we used different dosage of thioridazine to test its effect on lung cancer...
متن کاملThioridazine hydrochloride
Major uses Thioridazine hydrochloride (further thioridazine) is a representative of phenothiazine compounds, and it is an antipsychotic drug (synthesized in 1959). It relieves tension and anxiety, and acts against multiple symptoms, e.g. agitation, depression, behavior problems and sleep disturbances. Thioridazine is also effective in controlling the symptoms of schizophrenia, mania, and other ...
متن کاملThioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer.
Thioridazine, an antipsychotic drug, has been reported to induce apoptosis in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs). However, whether it elicits anticancer effects in gastric cancer has never been reported. In the present study, we examined the ability of thioridazine to induce cell death in the gastric cancer cell lines NCI-N87 and AGS, and detec...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The British journal of ophthalmology
دوره 56 2 شماره
صفحات -
تاریخ انتشار 1972