Turning fat into muscle

نویسنده

  • Heather L. Van Epps
چکیده

Mature DCs and the NKT cell ligand -galactosyl ceramide ( -GalCer) are a promising combination for boosting immunity in humans, according to a study on page 1503. Chang and colleagues used -GalCer–pulsed DCs to immunize cancer patients and showed that the treatment resulted in long-term expansion of both NKT cells and virus-specific CD8 T cells. -GalCer, a glycolipid derived from marine sponges, was identified based on its antitumor properties. This foreign glycolipid was later found to be presented to NKT cells by DCs. NKT cells activated by this glycolipid can promote tumor regression in mice. Attempts to extend this work to humans, however, have met with limited success. -GalCer treatment alone decreased NKT cell numbers in patients with solid tumors, and vaccination with -GalCer–pulsed immature DCs induced only modest and transient NKT cell expansion. Maturation of the DCs—treatment with cytokines that enhance the expression of MHC and costimulatory molecules—was the key to the approach used by Chang and colleagues. They immunized five advanced cancer patients, none of whom had detectable NKT cells in their blood before treatment. But with -GalCer–pulsed mature DCs, all patients had a rapid and sustained increase in NKT cell numbers. Surprisingly, CD8 T cells specific for cytomegalovirus were also expanded by -GalCer–pulsed DCs activate NKT cells and antiviral T cells in advanced cancer patients.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Turning on Brown Fat and Muscle Metabolism: Hedging Your Bets

Developmental genes are essential in the formation and function of adipose tissue and muscle. In this issue of Cell, Teperino et al. demonstrate that noncanonical hedgehog signaling increases glucose uptake into brown fat and muscle. Modulation of developmental pathways may serve as a potential target for new treatments of diabetes and other metabolic disorders.

متن کامل

Reference Gene Selection in Adipose and Muscle Tissues of Fat-tailed Lori-Bakhtiari Lambs

BACKGROUND: Fat-tailed sheep breeds have a  unique  ability  to  tolerate  periods  of  negative  energy  balance  due to seasonal changes in feed availability. This ability is attributed to presence  of  fat-tail  as  a  body  energy  reserve, however the exact underlying  mechanisms  controlling  the  response  of adipose  tissue  depots  to variations in energy balance in fat-tailed breeds a...

متن کامل

The Association of Food Intake and Physical Activity with Body Composition, Muscle Strength and Muscle Function in Postmenopausal Women

Background and Objectives: Sarcopenia is explained as age-related reduction in muscle mass and performance. Some of the most important risk factors for sarcopenia include age, malnutrition, and sedentary life style. The aim of this study was to investigate the association of food intake and physical activity with body composition, muscle strength and muscle function in post-menopausal women. ...

متن کامل

Whole body and tissue cholesterol turnover in the baboon.

Cholesterol turnover was studied in four baboons by injecting [14C]cholesterol 186 days and [3H]cholesterol 4 days before necropsy, and fitting a two- or three-pool model to the resulting specific activity-time data. At necropsy, cholesterol mass and specific activity were determined for the total body (minus the central nervous system) and for many tissues. A pool model permits the estimation,...

متن کامل

Comparing the 6 weeks of high-intensity interval and continuous training with standard diet on desnutrin and FNDC5 genes expression after a period of high fat diet in subcutaneous adipose tissue and the quadriceps muscle tissue of obese male rats

Introdution: Obesity is a systemic disorder that disruption the regulation of the effective proteins; in fat metabolism (Desnurtin, FNDC5 it leads to resistance to insulin and Diabetes.  The aim of this study was comparing the 6 weeks of high-intensity interval and continuous training with standard diet on desnutrin and FNDC5 genes expression in subcutaneous adipose tissue and the quadrice...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of Experimental Medicine

دوره 201  شماره 

صفحات  -

تاریخ انتشار 2005