Scintigraphic Findings and Serum Matrix Metalloproteinase 3 and Vascular Endothelial Growth Factor Levels in Patients with Polymyalgia Rheumatica
نویسندگان
چکیده
Objective: Polymyalgia rheumatica (PMR) is an inflammatory rheumatic disease that affects elderly people and is associated with synovitis. Recently, matrix metalloproteinase 3 (MMP 3) and vascular endothelial growth factor (VEGF) were reported to be involved in the pathogenesis of PMR-related synovitis. New evidence regarding the pathogenesis of PMR has been found; however, the diagnosis and outcomes of PMR remain uncertain. A more valid and standardized set of diagnostic criteria for PMR that preferably include laboratory and radiological assessment is required to facilitate the diagnosis of PMR, which is at present primarily based on the clinical symptoms. Methods: We performed gallium-67 scintigraphy to determine the distribution of inflammation in 6 patients with PMR; we also measured the serum C-reactive protein (CRP), MMP 3, and VEGF levels before and after corticosteroid administration. Results: Symmetrical gallium uptake was observed in the shoulders of all PMR patients, the pelvic girdles of 3 patients, the knees of 5 patients, and the wrists of 4 patients. The serum CRP, MMP 3, and VEGF levels were significantly elevated in pretreated PMR patients. Daily administration of 20 mg corticosteroid promptly and significantly decreased the serum CRP and VEGF levels. Moreover, the serum CRP levels were significantly correlated with the serum VEGF levels. Serum MMP 3 levels were increased in three patients and were decreased in two patients by daily administration of 20 mg corticosteroid. Conclusions: Gallium-67 scintigraphy demonstrated the existence of peripheral articular synovitis as well as proximal articular synovitis, which are common symptoms of PMR, in the study patients. The elevated serum VEGF levels before treatment promptly decreased after corticosteroid administration, suggesting the significant association of VEGF with the pathogenesis of PMR.
منابع مشابه
Clinical, radiological, and biochemical characteristics in patients with diseases mimicking polymyalgia rheumatica
To find out clues to differentiate between polymyalgia rheumatica (PMR) and other diseases that mimic PMR. We studied Japanese patients with PMR (n = 7), pseudogout (n = 1), remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome (n = 1), and post-infectious polyarthritis (n = 1). The distribution of inflammation in patients was evaluated using a gallium-67 scintigraphy...
متن کاملSerum vascular endothelial growth factor in Iranian patients with moderate-severe psoriasis before and after treatment: a PASI-75 response as a practical treatment goal
Background: Psoriasis is a chronic disease with multiple biochemical and vascular abnormalities. Several studies have evaluated circulating levels of vascular endothelial growth factor (VEGF) in psoriasis, but none of them evaluated it after reaching a PASI-75 response, as a practical treatment goal. The aim of this study was to evaluate serum levels of VEGF in moderate to severe psoriatic pati...
متن کاملThe Relationship of Serum levels of Vascular Endothelial Growth Factor with Disease Severity and the Number of Exacerbations in COPD Patients
Background: Chronic Obstructive Pulmonary Disease (COPD) is a chronic lung disease characterized by progressive and irreversible obstruction of the airways of the lungs. Different studies have emphasized on the role of Vascular Endothelial Growth Factor (VEGF) in COPD patients. The aim of this study was to investigate the relationship of this factor with disease severity and th...
متن کاملSerum and Peritoneal Fluid Levels of Vascular Endothelial Growth Factor in Women with Endometriosis
متن کامل
Pnm-9: Serum and Peritoneal Fluid Level of Vascular Endothelial Growth Factor in Endometriosis
Background: Endometriosis is known as one of the most common disease in women of reproductive age. Due to importance role of vascular endothelial growth factor (VEGF) in neo-vascularization for the implantation of endometrial cell and different reported results for VEGF level in the serum and peritoneal fluid (PF) in endometriosis patients, this study was designed to determine the serum and PF ...
متن کامل