VASCULAR BIOLOGY Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells
نویسندگان
چکیده
1Vascular Biology Program, Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia; 2Molecular Pathology Research Laboratory, Hanson Institute, SA Pathology, Adelaide, Australia; 3Department of Medicine, University of Adelaide, Adelaide, Australia; 4Centre for Vascular Research, Bosch Institute and Discipline of Pathology, School of Medical Sciences, Sydney Medical School, University of Sydney, Sydney, Australia; and 5Medical Foundation, University of Sydney, Sydney, Australia
منابع مشابه
Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells.
Cellular senescence is a mechanism to inhibit the growth of mammalian cells after oncogenic activation, or in response to damage or stress. We describe here the identification of a novel gene, SENEX, that regulates stress induced premature senescence pathways in endothelial cells (ECs) involving p16(INK4a) and retinoblastoma protein activation. Endogenous levels of SENEX remain unchanged during...
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