NEPHROLOGY - REVIEW Abnormalities of serum potassium concentration in dialysis- associated hyperglycemia and their correction with insulin: a unique clinical/physiologic exercise in internal potassium balance

The absence of significant losses of potassium in the urine makes dialysis-associated hyperglycemia (DH) a model for the study of the internal potassium balance. Studies of DH have revealed that hyperkalemia is frequent at presentation, insulin infusion is usually the only treatment required, and the magnitude of the decrease in serum potassium concentration (K) during treatment of DH with insulin depends on the starting serum K level, the decreases in serum glucose concentration and tonicity, and the increase in serum total carbon dioxide level. We present an analysis of these findings based on previously studied actions of insulin. Calculations of transcellular potassium shifts based on the combined effects of insulin—the increase in the electrical potential differences (hyperpolarization) of the cell membranes and the correction of the hyperglycemic intracellular dehydration through decrease in serum glucose concentration— produced quantitative predictions of the decrease in serum K similar to the reported changes in serum K during treatment of DH with insulin. The lessons from analyzing serum K changes during treatment of DH with insulin are applicable to other conditions where internal potassium balance is called upon to protect serum K, such as the postprandial state. The main questions related to internal potassium balance in DH that await clarification include the structure and function of cell membrane potassium channels, Electronic supplementary material The online version of this article (doi:10.1007/s11255-010-9831-7) contains supplementary material, which is available to authorized users. A. H. Tzamaloukas G. H. Murata Medicine Service, New Mexico Veterans Affairs Health Care System, Albuquerque, NM, USA A. H. Tzamaloukas M. Rohrscheib G. H. Murata Department of Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA T. S. Ing Medicine Service, Loyola University School of Medicine, Hines, IL, USA M. S. Elisaf K. C. Siamopoulos Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece D. S.C.Raj Division of Nephrology, George Washington University School of Medicine, Washington, DC, USA A. H. Tzamaloukas (&) Renal Section (111C), Raymond G. Murphy VA Medical Center, 1501 San Pedro, SE, Albuquerque, NM 87108, USA e-mail: [email protected] 123 Int Urol Nephrol DOI 10.1007/s11255-010-9831-7