No Significant Risk Levels (nsrls) for the Proposition 65 Carcinogens Methylhydrazine and Methylhydrazine Sulfate
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چکیده
The cancer potency of methylhydrazine by the inhalation route was estimated from dose-response data for multiple methylhydrazine-responsive tumor sites among female mice exposed by inhalation (Kinkead et al., 1985). These sites were nasal and respiratory mucosa, lung, liver, and blood vessels. For each of these tumor sites, a probability distribution of cancer potency estimates was derived using likelihood theory. The linear term (q1) of the multistage model fit to dose response data for a given site represents the cancer potency for that site. A combined distribution representing cancer potency for all sites affected by methylhydrazine (by the inhalation route) was derived through Monte Carlo analysis. The upper 95 percent confidence bound indicated by the combined distribution for the methylhydrazine related tumor sites was taken as the cancer potency for inhalation exposures.
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This is the Final Statement of Reasons for specific regulatory levels for 22 chemicals listed as known to the State to cause cancer or reproductive toxicity under the Safe Drinking Water and Toxic Enforcement Act of 1986 (hereinafter the Act or Proposition 65), popularly known as “Proposition 65.” On June 8, 2001, the Office of Environmental Health Hazard Assessment (OEHHA) issued a Notice of P...
متن کاملEXPEDITED CANCER POTENCY VALUES AND NO SIGNIFICANT RISK LEVELS (NSRLs) FOR SIX PROPOSITION 65 CARCINOGENS: CARBAZOLE, MeIQ, MeIQx, METHYL CARBAMATE, 4-N-NITROSOMETHYLAMINO)-1-(3-PYRIDYL)-1- BUTANONE, TRIMETHYL PHOSPHATE
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