ression of Noncoding Vault RNA in Human Malignant Cells
نویسندگان
چکیده
Download ral noncoding RNAs do vital cellular functions, including gene regulation and cell differentiation. Pre, we reported that vault RNA (vRNA) has the ability to recognize chemotherapeutic compounds, such oxantrone, based on biophysical and biochemical analyses. In the present study, we show that human stoma-, leukemia-, and osteocarcinoma-derived cell lines overexpress vRNA and exhibit higher resistoward mitoxantrone. Interestingly, when vRNA expression was suppressed by RNA interference in cells, the resistance progressively decreased. In agreement with these findings, overexpression of -1 caused resistance to mitoxantrone. These results suggest a role of vRNA in mitoxantrone resistance in malignant cells and justify further studies on the importance and application of noncoding RNAs in cancer chemotherapeutics. Mol Cancer Res; 8(11); 1536–46. ©2010 AACR.
منابع مشابه
Expression of noncoding vault RNA in human malignant cells and its importance in mitoxantrone resistance.
Several noncoding RNAs do vital cellular functions, including gene regulation and cell differentiation. Previously, we reported that vault RNA (vRNA) has the ability to recognize chemotherapeutic compounds, such as mitoxantrone, based on biophysical and biochemical analyses. In the present study, we show that human glioblastoma-, leukemia-, and osteocarcinoma-derived cell lines overexpress vRNA...
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