Ciprofloxaci Dosage and Emergence of Resistance in Human Commensal Bacteria
نویسندگان
چکیده
Bruno Fantin, Xavier Duval, Laurent Massias, Loubna Alavoine, Françoise Chau, Sylvie Retout, Antoine Andremont, and France Mentré Université Paris Diderot, EA3964, “Emergence de la résistance bactérienne in vivo,” Université Paris Diderot, AP-HP Hôpital Beaujon, AP-HP Hôpital Bichat, INSERM CIC 007, INSERM UMR 738, Laboratoire de Toxicologie et Pharmacocinétique, Service de Pharmacie, and CNR “Résistance dans les flores commensales,” AP-HP Hôpital Bichat, Paris, France
منابع مشابه
Ciprofloxacin dosage and emergence of resistance in human commensal bacteria.
BACKGROUND Although optimization of the fluoroquinolone dosage increases the efficacy of this class of drugs against bacterial infections, its impact on the emergence of resistance in commensal bacteria is unknown. METHODS Six different 14-day dosages of oral ciprofloxacin were randomly assigned to 48 healthy volunteers. Individual pharmacokinetic and pharmacodynamic parameters combining anti...
متن کاملAnimal antibiotic use has an early but important impact on the emergence of antibiotic resistance in human commensal bacteria.
Antibiotic use is known to promote the development of antibiotic resistance, but substantial controversy exists about the impact of agricultural antibiotic use (AAU) on the subsequent emergence of antibiotic-resistant bacteria among humans. AAU for animal growth promotion or for treatment or control of animal diseases generates reservoirs of antibiotic-resistant (AR) bacteria that contaminate a...
متن کاملTracking Acquired Antibiotic Resistance in Commensal Bacteria of Galápagos Land Iguanas: No Man, No Resistance
BACKGROUND Antibiotic resistance, evolving and spreading among bacterial pathogens, poses a serious threat to human health. Antibiotic use for clinical, veterinary and agricultural practices provides the major selective pressure for emergence and persistence of acquired resistance determinants. However, resistance has also been found in the absence of antibiotic exposure, such as in bacteria fr...
متن کاملIncidence of Virulence Determinants and Antibiotic Resistance in Lactic Acid Bacteria Isolated from Iranian Traditional Fermented Camel Milk (Chal)
Lactic acid bacteria, including lactobacilli, enterococci, leuconostoc and weissella species isolated from Iranian traditional fermented camel milk (Chal) were assessed for the incidence of virulence determinants (gelE, efaAfm, efaAfs, ace, espfs, cylM, cylA and cylB), sensitivity to various antibiotics and virulence phenotypes. The incidence of virulence genes was determined by polymerase cha...
متن کاملQuinolone Resistance in Oligella Urethralis-Associated Urinary Tract Infection
The importance of oxidase-positive, nonfermentative, Gram-negative bacilli in a variety of pathological processes is becoming increasingly important. Oligella urethralis is an organism which is normally isolated as a commensal from the genitourinary tract. We have described one case of urinary tract infection caused by this organism. This isolated organism is found to be resistant to quinolones...
متن کامل