Pharmacokinetics of the treatment switch from efavirenz to nevirapine.

Figure 1. Efavirenz (week 0) and nevirapine (weeks 2–12) plasma concentrations during the switch from efavirenz to nevirapine (for 18 patients). The box plot shows a comparison of the plasma concentrations, with the upper and lower edges of the boxes representing upper and lower quartiles, respectively. Lines extending above and below the boxes represent the highest and lowest values, respectively. Circles represent outliers. Plus signs represent the mean values of the nevirapine plasma levels, and the small white square inside the first interquartile range (IQR) box represents the mean value of the efavirenz plasma level. The horizontal line within each IQR box respresents the median value of the nevirapine or efavirenz plasma level. Reprints or correspondence: Dr Helen Kovari, Div of Infectious Diseases and Hospital Epidemiology, University Hospital, CH8091 Zurich, Switzerland ([email protected]). Clinical Infectious Diseases 2010; 50(11):1546–1547 2010 by the Infectious Diseases Society of America. All rights reserved. 1058-4838/2010/5011-0023$15.00 DOI: 10.1086/652717