Cyclopia and Anophthalmia Phenotype Abnormalities and a Partially Penetrant mFAT1 Exhibit Renal Slit Junction Mice Lacking the Giant Protocadherin
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منابع مشابه
Signaling at the slit diaphragm.
Diseases of the glomerular filter of the kidney are a leading cause of end-stage renal failure. Recent studies have emphasized the critical role of the slit diaphragm of podocytes for the size-selective filtration barrier of the kidney and revealed novel aspects of the mechanisms that lead to proteinuria, in both inherited and acquired diseases (1–4). Several critical structural protein compone...
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The mammalian Protocadherin (Pcdh) alpha, beta, and gamma gene clusters encode a large family of cadherin-like transmembrane proteins that are differentially expressed in individual neurons. The 22 isoforms of the Pcdhg gene cluster are diversified into A-, B-, and C-types, and the C-type isoforms differ from all other clustered Pcdhs in sequence and expression. Here, we show that mice lacking ...
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